Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation

Previous studies have suggested that microwave (MW) radiation with certain parameters can induce spatial memory deficits. However, the effect of MW on topological organization brain network is still unknown. This work aimed to investigate in rats impairments induced by acute radiation. The Morris water maze (MWM) test and resting-state functional magnetic resonance imaging were performed estimate ability after exposure. Compared sham group, exposed 30 mW/cm2 1.5 GHz exhibited a significantly decreased normalized clustering coefficient (γ) (p = 0.002) 1 d exposure prolonged average escape latency (AEL) 0.014) 3 Moreover, 10 radiation, γ 0.003) was also observed rats, without any changes AEL. In contrast, no adverse effects AEL or 9.375 conclusion, deficits disruptions network. these emerged earlier than behavioral symptom onset could even be found decline performance task. Therefore, it possible use as early sensitive indicators